|
rs8057341
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
rs8056611
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.
|
18680223 |
2008 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Asp299Gly and Thr399Ile variants do not show an association with CD, UC, or IBD as a group, indicating that these polymorphisms are likely not the causal ones.
|
15905704 |
2005 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
D299G and T399I were related to CD only in patients carrying NOD2 variants (NOD2+/TLR4+ haplotype) (p=0.036; OR=1.924), increasing the risk to develop CD when 1007insC and TLR4 variants were both present (OR=4.886).
|
27290609 |
2016 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC.
|
15194649 |
2004 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This is underscored by the finding of the association between CARD15 variants and Crohn's disease (CD) and D299G in Toll-like receptor (TLR) 4 and IBD.
|
16374251 |
2006 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
90 patients with CD and 80 healthy individuals are genotyped for the Asp299Gly and Thr399Ile polymorphisms by restriction fragment length polymorphism analysis.
|
19664207 |
2009 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TLR4 Asp299Gly polymorphism is a risk factor for CD.
|
15973118 |
2005 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a geographic area in Southern Italy with high incidence of CD we investigated IP (lactulose/mannitol testing) together with the three main mutations of the NOD2/CARD15 and the D299G polymorphism of the toll-like receptor (TLR)-4 gene in 23 families of CD patients (patients and first-degree relatives).
|
16393227 |
2005 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (CD) (n = 379; German n = 235, Hungarian n = 144) and ulcerative colitis (UC) (n = 263; German n = 145, Hungarian n = 118) and healthy controls (n = 605; German n = 403, Hungarian n = 202) were genotyped for the presence of the CD14 c.1-260C>T promoter variant and the TLR4 c.896A>G (p.D299G) variant by melting curve analysis using fluorescence resonance energy transfer probes.
|
18174680 |
2007 |
|
rs771184127
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population.
|
18213697 |
2008 |
|
rs758548184
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In all subjects, just one band of 151 bp, corresponding to wild-type N852S, was found, and no other N852S mutant bands (151+129+22 and 129+22 bp) were detected using PCR-RFLP fragment electrophoresis.The CTLA-4 gene +49 A/G polymorphism and the NOD2/CARD15 gene N852S polymorphism were not associated with CD or UC in a Turkish population.
|
30213296 |
2018 |
|
rs751271
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
rs749910
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
rs747581406
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphisms (SNPs) -1237T/C (rs5743836) and 2848A/G (rs352140=p.Pro545Pro) in TLR9, the main CD-associated variants within the genes for NOD2, IL23R, ATG16L1, and variants in the IBD5 locus and in the DLG5 gene were assessed in 956 patients with IBD (606 CD and 350 ulcerative colitis) and in 792 healthy controls.
|
19455129 |
2009 |
|
rs72796367
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs72796353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast to the strong associations of the NOD2 SNPs rs2066844 (p=3.51 x 10(-3)), rs2066845 (p=1.54 x 10(-2)), and rs2066847 (p=1.61 x 10(-20)) with CD susceptibility, no significant association of rs72796353 with CD or UC susceptibility was found.
|
26147989 |
2015 |
|
rs62029861
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Using this approach, eight novel amino acid substitutions [c.1171C>T (p.R391C), c.1387C>G (p.P463A), c.2138G>A (p.R713H), c.2278C>T (p.R760C), c.2368C>T (p.R790W), c.2371C>T (p.R791W), c.2475C>G (p.N825K), and c.2546C>T (p.A849V)] were detected in six CD and two IC patients, and one UC patient.
|
16485124 |
2006 |
|
rs62029861
|
|
|
0.710 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs61747625
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.
|
27812135 |
2016 |
|
rs61747625
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
Crohn disease: frequency and nature of CARD15 mutations in Ashkenazi and Sephardi/Oriental Jewish families.
|
15024686 |
2004 |
|
rs61747625
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease.
|
16485124 |
2006 |